Early Plasmodium -induced inflammation does not accelerate aging in mice

Sod2 haploinsufficiency does not accelerate aging of telomere dysfunctional mice

Telomere shortening represents a causal factor of cellular senescence. At the same time, several lines of evidence indicate a pivotal role of oxidative DNA damage for the aging process in vivo. A causal connection between the two observations was suggested by experiments showing accelerated telomere shorting under conditions of oxidative stress in cultured cells, but has never been studied in v...

Does Vascular Calcification Accelerate€Inflammation?

Fro F. xU Mo Ma Aa Ka AG ed aw Ins Ho ho res VB BACKGROUND Atherosclerosis is an inflammatory condition with calcification apparent late in the disease process. The extent and progression of coronary calcification predict cardiovascular events. Relatively little is known about noncoronary vascular calcification. OBJECTIVES This study investigated noncoronary vascular calcification and its influ...

Tumor Necrosis Factor- Does Not Mediate Diabetes-Induced Vascular Inflammation in Mice

Allergic inflammation does not impact chemical-induced carcinogenesis in the lungs of mice

BACKGROUND Although the relationship between allergic inflammation and lung carcinogenesis is not clearly defined, several reports suggest an increased incidence of lung cancer in patients with asthma. We aimed at determining the functional impact of allergic inflammation on chemical carcinogenesis in the lungs of mice. METHODS Balb/c mice received single-dose urethane (1 g/kg at day 0) and t...

TRIF Deficiency does not Affect Severity of Ovalbumin-induced Airway Inflammation in Mice

Allergic asthma is a chronic pulmonary inflammatory disease characterized by reversible airway obstruction, hyperresponsiveness and eosinophils infiltration. Toll-like receptors (TLRs) signaling are closely associated with asthma and have emerged as a novel therapeutic target in allergic disease. The functions of TLR3 and TLR4 in allergic airway inflammation have been studied; however, the prec...